Over the past decade, small molecule kinase inhibitors have emerged as promising therapeutics, particularly in oncology. Through data that has emerged during this period, it has become increasingly ...

Kinases constitute a family of more than 500 enzymes and play critical roles in cellular signaling, both in normal and diseased cells. As a result, kinases continue to be key drug targets, especially ...

Establishing that a molecule engages with its intended target protein in cells is an essential step in drug discovery and chemical probe development. The term “target engagement” refers to a chemical ...

This poster was originally authored by John Vincent, Matthew Burnham, Gerrit Daubner, and Martin Main of the Medicines Discovery Catapult. It was presented at ELRIG Drug Discovery 2023. Methods to ...

Developing new pharmaceuticals is a complex and costly process that requires innovation and efficiency. High-throughput immunoassays (HTIs) are an emerging technology poised to accelerate the drug ...