Figure 1: Structure based ligand discovery for the μOR. Figure 2: Discovery of a novel G i/o-biased μOR agonist. Figure 3: Structure-guided optimization towards a potent biased μOR agonist. Figure 4: ...

Opium extracts from the plant Papaver somniferum have been used for therapeutic and recreational purposes for thousands of years. Opioid alkaloids and related pharmaceuticals are the most effective ...

Overview: Morphine is used to treat short-term and long-term pain when other medicines are not enough. It keeps you from feeling pain. Common side effects include constipation, itching, dizziness, and ...

Pain relief and other side effects of morphine usually wear off within 4–6 hours. It may still be present in the urine for 12–36 hours and in the blood for 1.5–4.5 hours. Morphine is a potent opioid ...

In the UK and US, patients who need morphine get it - it's a different story elsewhere It's cheap, effective and easy to administer - so why are millions of people around the world dying in pain, ...