Here in the Picks Department, we’re still trying to get through the 2025 NFL season with winning records overall and in Best Bets. Week 18 figures to make that difficult with its variety of playoff and tanking scenarios. Unless those things turn out to make it easier.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 18 on a 53-37 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

On Saturday, the NFL has two games with divisional titles on the line. First up, at 4:30 p.m. ET, the NFC South is on the line when the Tampa Bay Buccaneers (7-9) host the Carolina Panthers (8-8). At 8 p.m. ET, the Seattle Seahawks (13-3) travel to the Bay to play the San Francisco 49ers (12-4). You can catch both of these games on ABC/ESPN.

All three SI panelists who submitted an upset pick for Week 17 cashed in. Matt Verderame correctly predicted the Houston Texans to take down the Los Angeles Cha

The holiday season is upon us, and that coincides with the action across the NFL ramping up with just two weeks remaining in the 2025 regular season. As we head toward the finish line, plenty still needs to be determined,

Overall picks to win: 8-8 in Week 17 (173-82-1 for the season) Picks to win with 1-5 confidence: 4-7 (103-64-1) Picks to win with 6-10 confidence: 4-1 (70-18) Overall to cover the spread: 9-6-1 (130-117-9) Cover-the-spread picks with 1-5 confidence: 8-4-1 (107-93-8) Cover-the-spread picks with 6-10 confidence: 1-2 (23-23-1)