Despite progress in cancer biology, deciphering the spatial architecture of the tumor microenvironment remains a challenge. Traditional approaches lack the resolution to map cell-type-specific gene ...

Scientists have identified a new CAF subset in HNSCC using tissue cytometry and spatial transcriptomics. In two-thirds of cases, head and neck squamous cell carcinomas (HNSCC) require treatment with ...

Biological tissues are made up of different cell types arranged in specific patterns, which are essential to their proper ...

Factors Affecting Genomic Testing in Prostate Cancer: Results From the Decision-Making, Experience, and Confidence In Determining Genomic Evaluation (DECIDE) Survey We validated a clinical ...

Exploring biology in its native environment is perhaps the ideal scenario for generating better hypotheses about the cellular interactions that influence—and drive—healthy and diseased states, ...

Spatial omics is transforming how researchers understand tissue biology, revealing the complex interplay between cells in health and disease. While RNA expression studies provide important molecular ...

Scientists are using artificial intelligence to better capture how healthy cells surrounding tumors influence cancer cell behavior and how those interactions can inform treatments. Even cells ...

This figure shows how the STAIG framework can successfully identify spatial domains by integrating image processing and contrastive learning to analyze spatial transcriptomics data effectively.