The 49ers square off against the Colts and their newly un-retired quarterback on Monday Night Football in Week 16.

San Francisco 49ers quarterback Brock Purdy (13) runs the ball past Tennessee Titans linebacker Cedric Gray, left, during the ...

San Francisco 49ers coach Kyle Shanahan has shared some concerning news following the team's win over the Tennessee Titans.

San Francisco 49ers head coach Kyle Shanahan has made a shocking admission about the fallout with Brandon Aiyuk.

The San Francisco 49ers beat the Tennessee Titans on Sunday, and in the locker room they celebrated their coach's birthday.

On the defensive side, two staples to their core went down with season-ending injuries. Defensive end Nick Bosa tore his ACL ...

San Francisco 49ers coach Kyle Shanahan called the decision to put missing receiver Brandon Aiyuk on a season-ending reserve ...

The San Francisco 49ers are set to part ways with WR Brandon Aiyuk, and head coach Kyle Shanahan didn't mince words when ...

The San Francisco 49ers beat the Tennessee Titans on Sunday at Levi's Stadium. Here's what Kyle Shanahan had to say about his ...

The San Francisco 49ers placing wide receiver Brandon Aiyuk on the reserve/left squad list would seemingly be a distraction ...

The San Francisco 49ers have had a strong season while overcoming impactful injuries, but Kyle Shanahan says it isn't the ...

A week ago, Philip Rivers shocked the NFL when he decided to work out with the Colts amid injuries to quarterbacks Daniel ...