San Francisco 49ers head coach Kyle Shanahan opens up about facing veteran quarterback Philip Rivers of the Indianapolis ...

The 49ers square off against the Colts and their newly un-retired quarterback on Monday Night Football in Week 16.

Kyle Shanahan explains the 49ers' pregame roster moves and what Jordan Watkins must do to earn more playing time this season.

Ricky Pearsall is facing another injury setback. He had six catches for 96 yards on Sunday, helping the San Francisco 49ers ...

Brandon Aiyuk’s time with the San Francisco 49ers continues to look like it’s all but over. He just had an odd post, too, after coach Kyle Shanahan’s comments about him. Aiyuk hasn’t played football ...

The San Francisco 49ers are trending the right way from a health perspective entering a Week 16 showdown with the Indianapolis Colts.

San Francisco 49ers coach Kyle Shanahan has shared some concerning news following the team's win over the Tennessee Titans.

The San Francisco 49ers are headed to Indianapolis for a Week 16 matchup against the Colts, and they now officially know who ...

The most recent move the San Francisco 49ers made involving Brandon Aiyuk suggested he may never suit up for this team again.

On Sunday, the 49ers beat Tennessee 37-24, and Aiyuk's replacement, Ricky Pearsall, had six catches for 96 yards. So before ...

San Francisco 49ers quarterback Brock Purdy looked like a basketball player with an impressive touchdown pass on Sunday.

Brock Purdy delivered a signature moment in Sunday's win over the Titans, using his legs to key a 95-yard scoring drive.