Glial Cell Communities Conspire to Drive Alzheimer’s Disease
Sep 26, 2024 · The amyloid cascade—plaques to tangles to cognitive decline—has become well established. Less well understood is what role inflammation and glial changes play. Now, by …
New Role for Tau: Making Lipid Droplets in Glia? | ALZFORUM
Oct 22, 2024 · When they cranked up tau expression in glia throughout the fly brain, glial lipid droplets plummeted by more than 90 percent, and peroxidated lipids accumulated. Similarly, in …
Amelioration of Tau and ApoE4-linked glial lipid ... - ALZFORUM
Nov 29, 2023 · Here, Alexandra Litvinchuk from David Holtzman’s laboratory investigated the effect of the LXR agonist GW3965 as well as overexpression of ABCA1 on tau and apoE4 …
Regulation of cell distancing in peri-plaque glial nets by
Jun 5, 2024 · Important features of signaling within the glial nets—e.g., the identity of the Plexin-B1 ligand, how Plexin-B1 activation in astrocytes affects the physiology of microglia—remain …
Sans Plexin-B1, Glial Net Tightens Around Plaques - ALZFORUM
Jun 1, 2024 · Plexin-B1 expression by astrocytes imposes cell spacing in glial nets. Without Plexin-B1, glia huddle more closely together, and with plaques. The result? Smaller plaques, …
In Alzheimer Brain, Can Synaptic Pruning Be Good? | ALZFORUM
Sep 8, 2023 · In the Alzheimer’s disease brain, synaptic loss correlates with cognitive decline, and is considered a sign of disease progression. But is synaptic loss always bad? Provocative new …
While a Fly Sleeps, Its Glia Burn Neuronal Lipids to Refresh the …
Feb 27, 2024 · Further, neuronal but not glial mitochondria became oxidized. This suggests that neurons were indeed the source of the peroxidated lipids and that, by shuttling them to glia, …
Transcriptomics Paint Astrocytes as Source of Cognitive Resilience
Jul 26, 2024 · Glial cells responded more consistently across regions, and the researchers pegged astrocytes as the lone cell type in which gene expression synced strongly with …
Glial lipid droplets resolve ROS during sleep. | ALZFORUM
Feb 27, 2024 · Most previous work on this process focused on disease conditions. However, Haynes and colleagues discovered that glial lipid droplet accumulation occurs as part of a …
Neuron-Glia Crosstalk Underlies Senescence, Impaired Lipid
Jun 7, 2024 · They found that waning mitochondrial function in neurons triggered glial senescence. In turn, these senescent glia perturbed lipid metabolism in neighboring, healthy …